| Thesis Details |
 Title | Modelling Human Immunodeficiency Virus and
Hepatitis C Virus Epidemics in Australia |
|
Author | Gao, Zhanhai |
|
Institution | University of New South Wales |
|
Date | 2001 |
|
Abstract | This thesis is concerned with the mathematical modelling
for human immunodeficiency virus (HIV) and
hepatitis C virus (HCV) epidemics in Australia.
There are two parts to this thesis. Part I is aimed at modelling the
transmission of HIV and HCV via needle sharing among
injecting drug users (IDUs).
The dynamical model of an epidemic through needle sharing
among IDUs is derived. This model reveals the correlation between
needle sharing and the epidemic prevalence among IDUs.
The simulations of HIV and HCV prevalence and incidence among IDUs in Australia
are made with this model. The comparison of simulated results
with literature estimates shows that the modelled results are consistent with
the literature estimates. The effects of needle sharing and cleaning
on HIV and HCV prevalence and
incidence among IDUs in Australia are evaluated.
Part II is devoted to modelling the spread of HIV in
the general community in Australia. A mathematical model is formulated to
assess the epidemiological consequences of injecting drug use and sexual
transmission in Australia. The effects of highly active antiretroviral
therapies (HAART) on the HIV epidemic are included.
The modelled results are in broad agreement with the literature estimates and
observed data. The long-term effects of HAART are also discussed.
|
| Thesis
|
01front.pdf 76.9 Kb
02whole.pdf 940.5 Kb
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